FIG 1 .
The dynamics of susceptibility to postinfluenza pneumococcal infection. Age-matched male mice were i.n. infected with IAV (30 PFU) or were left uninfected (0 dpi). Four, 7, or 14 days later, the mice were challenged with S. pneumoniae (103 CFU). The number of bacteria was determined in lungs (A) and spleen (B) 30 h after S. pneumoniae challenge. The solid lines correspond to the median values. Results from a pool of two experiments are shown. ns, not significant. *, P < 0.05; ***, P < 0.001 (one-way ANOVA Kruskal-Wallis test).