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Ciprofloxacin binds to and blocks channel conductance. (a) Transient blockages are observed in the ion-current trace of single trimeric rMOMP channel in the presence of 1 M KCl, 10 mM Mes, and 10 mM CaCl2 (pH 6.0) when 0.5 mM ciprofloxacin is added to trans side. The applied transmembrane potential was + 150 mV. (b) The number of binding events increases with the increase in the concentration of the ciprofloxacin from 0.25 to 1 mM measured at 150 mV.
