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Kinetics of ciprofloxacin entry into MOMP channel
| Rate constants | 0.5 mM ciprofloxacin |
|---|---|
| kon cis (× 103 M− 1 s− 1) | 47 ± 10 |
| kon trans (× 103 M− 1 s− 1) | 73 ± 7 |
| koff (× 103 s− 1) | 16 ± 1 |
Experimental conditions: 1 M KCl, 10 mM Mes, 10 mM CaCl2, and 0.5 mM ciprofloxacin (pH 6.0); T = 20 °C. The applied transmembrane voltage was 150 mV.
