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. 2016 Oct 19;6(10):160109. doi: 10.1098/rsob.160109

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© 2016 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 5. — Transactivation properties of distinct mouse Foxd1 versions on Pgf and C3 promoters. (a) Luciferase activity on the mouse Pgf promoter in two cell models (COS-7 and KGN). In black are the effects of the Mus musculus and Mus spretus versions of Foxd1 on the Mus musculus promoter. In red are the effects of the same TFs on the Mus spretus promoter. The expression profiles are similar, despite significant differences in the cell lines. Overall, the activation of the promoter appears more efficient with the Mus musculus FoxD1. (b) The effects of specific variants of FoxD1, including the T152A mutation on the Pgf and C3 promoters. The Mus spretus variant appears more efficient on the C3 promoter and less efficient on the Mus musculus version of the Pgf promoter. These results are consistent with an overexpression of complement cascades (negative for implantation) and underexpression of a major actor of placental angiogenesis, Pgf. p-values *<0.05, **<0.01 and ***<0.001.