Table 1.

Hyperactive Hippo pathway and diseases.

disease	Hippo components	affected organ or tissue	evidence	references
arrhythmogenic cardiomyopathy	NF2, MST1/2, LATS1/2 and YAP	heart	gene expression	[7]
Sveinsson's chorioretinal atrophy	TEAD1	eye	human, mouse mutation	[8,9]
retinal detachment	MST2	eye	gene expression	[10]
Alzheimer's disease	MST1/2, YAP	brain, nerves	gene expression	[11,12]
skeletal muscle atrophy	MST1, YAP?	muscles, nerves	gene expression	[13]
amyotrophic lateral sclerosis	MST1, YAP	nerves	gene expression	[14,15]
diabetes	MST1	multiple	gene expression	[16]