Figure 1.

(A) Pro-lymphangiogenic growth factor gene expression, as measured by qPCR is increased during early and late involution in whole rat mammary tissues [adapted from Lyons et al. (38)]. (B) Lyve-1+ lymphatic vessels per area (left axis) is increased during pregnancy and again during involution in mouse mammary tissues with peak levels observed at day 6. (Right axis) A previous study showing a similar increase in Prox-1+ lymphatic vessels during pregnancy as well as levels at involution day 10 [adapted from Betterman et al. (91)].