Table 2. Independent genetic associations of RGS1 and RASGRP1 variants in IgA nephropathy.
| Chr | SNP | IgAN discovery |
IgAN replication |
IgAN in total |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAF case/control (%) | P | OR | 95% CI of OR | MAF case/control (%) | P | OR | 95% CI of OR | P | OR | 95% CI of OR | ||
| 1 | rs12022418 | 36.48/31.67 | 6.27 × 10−4 | 1.24 | 1.10–1.40 | 37.00/32.13 | 2.88 × 10−3 | 1.15 | 1.05–1.26 | 3.00 × 10−6 | 1.23 | 1.13–1.34 |
| 15 | rs7170151 | 49.39/44.47 | 8.34 × 10−4 | 1.22 | 1.09–1.37 | 49.80/45.27 | 9.05 × 10−3 | 1.20 | 1.05–1.38 | 1.90 × 10−5 | 1.20 | 1.10–1.30 |
Discovery cohort: 1,248 patients with sporadic IgAN, and 1,187 controls.
Replication cohort: 500 patients with sporadic IgAN, and 2,372 controls.