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. 2016 Nov 2;6:35636. doi: 10.1038/srep35636

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Real time multiphoton imaging of 5 in brains of APP ^+/−/PS1^+/− transgenic mice: Following demarcation of blood vessels with dextran-Texas Red, 5 (2 mg/kg) was intravenously injected. A z-stack image series was acquired using an LSM 510META NLO microscope (Carl-Zeiss Inc). While arrowhead indicates vascular Aβ, the arrow shows parenchymal plaques.