Table 4. Final genetic model for predicting late-onset Alzheimer’s disease.

Variables	Coefficient	Point
Age groups
65–75	0	0
>75	2.42	7
Sex
Men	0	0
Women	0.37	1
Education
>6 years	0	0
≤6 years	2.11	6
APOE e4 status
Non-carriers	0	0
Carriers	0.91	2
rs4420638 (APOC1)
Non-carriers	0	0
Carriers	0.64	2
Total range		0–18
Mean score ± SD		6.2 ± 5.1
AUC (95% CI)		0.87 (0.83–0.90)
Corrected for optimism		0.866

Abbreviations: SD, sample standard deviation; AUC, area under the receiver operating characteristic curve; CI, confidence interval.

The correction for optimism was performed by leave-one-out cross-validation (LOOCV) in stage 2 (validation set).