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. 2016 Nov 2;6:36222. doi: 10.1038/srep36222

Figure 3. Metformin inhibits platelet activation in vivo and in vitro.

Figure 3

(A,B) Influence of metformin on aggregation of platelets induced by ADP, AA, and thrombin in vitro (metformin: 1 mM, 6 h) and in vivo (metformin: 400 mg/kg/d, 7 d). (C,D) Effect of metformin on platelet adhesion to collagen-coated surfaces (phalloidin-labelled platelets). (E,F) αIIbβ3 expression in ADP-activated platelets with metformin in vitro and in vivo. (G,H) P-selectin expression in ADP-activated platelets with treatment in vitro and in vivo. (I,J) Influence of metformin on the elevation of cytosolic calcium levels in ADP-stimulated platelets in vitro and in vivo. Data are expressed as mean ± SD. n = 9–10. *P < 0.05 vs control, #P < 0.05 vs ADP.