Table 2.
Sarilumab Clinical Trials
| Phase | Trial | Study Population | Efficacy Outcomes |
|---|---|---|---|
| I | Studies 801, 802, 803 | Active RA on methotrexate |
None evaluated. |
| II | ALIGN | Active Ankylosing Spondylitis despite conventional treatment |
No clinically significant responses. |
| II | MOBILITY Part A | Active RA despite treatment with methotrexate |
Significant ACR20 response at 12 weeks |
| III | MOBILITY Part B | Active RA despite treatment with methotrexate |
Sustained clinical efficacy including improved radiographic scores. |