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. 2016 Sep 19;8(11):1234–1247. doi: 10.15252/emmm.201606592

Figure EV1. Description of diet compositions, effects of mAD for serum parameters, enzyme histochemistry, and mtDNA amount and mutations.

Figure EV1

  • A
    Isocaloric mAD composition in PEO patients and control subjects. The amounts of fat, carbohydrates, and proteins are represented as kcal% from the total daily energy expenditure. Values shown as mean and SEM.
  • B
    Plasma FGF‐21 levels in individual patients and in grouped controls (n = 10) shown as mean ± SD.
  • C–H
    Plasma levels of alanine aminotransferase (P‐ALT), urea, triglycerides, cholesterol, glucose and insulin in PEO patients and control subjects. Controls (n = 10) are shown as mean ± SD. Dashed line: upper limit of control range.
  • I
    COX‐SDH histochemical activity analysis on frozen sections from quadriceps femoris muscle of the PEO patients in normal diet (ND) and after modified Atkins diet (mAD). Scale bar, 150 μm.
  • J
    Skeletal muscle, relative mtDNA amount compared to nuclear single‐copy APP gene.
  • K
    mtDNA deletion load as a percentage from total mtDNA in PEO muscle.
Data information: Abbreviations: mo, month; yr, year; fP, fasted plasma; COX, cytochrome c oxidase; SDH, succinate dehydrogenase.