Table 4. VH-IVUS measurements at baseline and at 8-month follow-up.

Lesion	Non-HDL cholesterol (mg/dl)
	≦ 140 (n = 38)	141–169 (n = 42)	≧ 170 (n = 39)	p value*
DC (VI, mm3/mm)
Baseline	0.51 ± 0.56	0.45 ± 0.34	0.33 ± 0.29	0.18
8-month follow-up	0.67 ± 0.62	0.56 ± 0.52	0.41 ± 0.27	0.18
Δ	0.16 ± 0.31	0.11 ± 0.36	0.08 ± 0.22	0.55
%Δ	81.1 ± 144	62.7 ± 131	81.9 ± 145	0.65
p value#	0.004	0.061	0.024
NC (VI, mm3/mm)
Baseline	0.83 ± 0.60	0.83 ± 0.60	0.57 ± 0.42	0.062
8-month follow-up	0.93 ± 0.65	0.90 ± 0.60	0.79 ± 0.50	0.67
Δ	0.10 ± 0.52	0.07 ± 0060	0.22 ± 0.54	0.47
%Δ	42.1 ± 98	45.5 ± 104	279 ± 173	0.46
p value#	0.25	0.47	0.014
FI (VI, mm3/mm)
Baseline	3.1 ± 1.6	3.5 ± 2.0	3.3 ± 1.9	0.66
8-month follow-up	3.2 ± 1.5	3.2 ± 1.8	2.9 ± 1.7	0.45
Δ	0.13 ± 0.85	− 0.24 ± 0.79	− 0.3 ± 0.73	0.004
%Δ	9.4 ± 26.7	− 2.7 ± 33.5	− 7.6 ± 26.6	0.003
p value#	0.37	0.054	0.005
FF (VI, mm3/mm)
Baseline	0.98 ± 0.66	1.1 ± 1.2	1.1 ± 0.84	0.54
8-month follow-up	0.72 ± 0.53	0.87 ± 0.84	0.86 ± 0.80	0.99
Δ	− 0.26 ± 0.53	− 0.22 ± 0.79	− 0.27 ± 0.77	0.61
%Δ	− 8.7 ± 62.3	5.6 ± 87.2	11.5 ± 189	0.55
p value#	0.004	0.074	0.037

Values are means ± SDs;

^*Analysis of variance or Kruskal-Wallis test as appropriate

^#Paired t-test or Wilcoxon test as appropriate; VH-IVUS, virtual histology intravascular ultrasound; DC, dense-calcium; NC, necrotic-core; FI, fibrous; FF, fibro-fatty; HDL, high-density lipoprotein; VI, volume index; PAV, Percent atheroma volume