Table 3. Hazard ratios (HRs) of incident chronic kidney disease according to quartiles of serum albumin levels.
| Quartiles of serum albumin |
||||
|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | |
| Men | ||||
| Number at risk | 174 | 262 | 152 | 233 |
| Person years | 1247 | 1984 | 1183 | 1787 |
| Number of cases (%) | 32 (18.4) | 41 (15.7) | 19 (12.5) | 31 (13.3) |
| Incidence, per 1000 person-years | 25.7 | 20.7 | 16.1 | 17.3 |
| Age and community-adjusted HR | 1.00 | 0.83 (0.52–1.32) | 0.69 (0.39–1.21) | 0.88 (0.53–1.46) |
| Multivariable HR# | 1.00 | 0.63 (0.38–1.04) | 0.64 (0.36–1.16) | 0.69 (0.40–1.17) |
| Women | ||||
| Number at risk | 349 | 634 | 301 | 430 |
| Person years | 2596 | 4831 | 2319 | 3464 |
| Number of cases (%) | 57 (16.3) | 96 (15.1) | 43 (14.3) | 48 (11.2) |
| Incidence, per 1000 person-years | 22.0 | 19.9 | 18.5 | 13.9 |
| Age and community-adjusted HR | 1.00 | 0.86 (0.62–1.19) | 0.82 (0.55–1.22) | 0.60 (0.41–0.88) |
| Multivariable HR# | 1.00 | 0.95 (0.68–1.34) | 0.82 (0.55–1.23) | 0.42 (0.28–0.64) |
| Total subjects | ||||
| Number at risk | 523 | 896 | 453 | 663 |
| Person years | 3844 | 6816 | 3502 | 5251 |
| Number of cases (%) | 89 (17.0) | 137 (15.3) | 62 (13.7) | 79 (11.9) |
| Incidence, per 1000 person-years | 23.2 | 20.1 | 17.7 | 15.0 |
| Sex, age and community-adjusted HR | 1.00 | 0.87 (0.66–1.13) | 0.78 (0.57–1.09) | 0.68 (0.51–0.93) |
| Multivariable HR# | 1.00 | 0.88 (0.67–1.15) | 0.78 (0.56–1.09) | 0.52 (0.38–0.72) |
#
The multivariable adjusted HR was further adjusted for body mass index, smoking status, systolic blood pressure, antihypertensive medication use, diabetes mellitus, serum total cholesterol, cholesterol-lowering medication use, estimated glomerular filtration rate, and high-sensitivity C-reac-tive protein levels.
Abbreviations: Q, quartile.