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. 2016 Sep;11(9):1438–1444. doi: 10.4103/1673-5374.191217

Figure 4.

Figure 4

Effect of carnosine on MBP expression in the corpus callosum in the mouse model of SIVD.

(A) Effect of carnosine on MBP expression in the corpus callosum was evaluated using the mean fluorescence intensity after right unilateral common carotid artery occlusion. The fluorescence indicator is FITC (green). Scale bar: 50 µm. (B) Quantitative analysis of MBP expression. The staining intensity for MBP was reduced in the SIVD group, and was increased by administration of carnosine (200, 500 mg/kg). Data are expressed as the mean ± SEM. n = 8–10 mice in each group. ##P < 0.01, vs. sham group; *P < 0.05, **P < 0.01, vs. SIVD group. I–V: Sham, SIVD, SIVD + carnosine 200 mg/kg, SIVD + carnosine 500 mg/kg and SIVD + carnosine 750 mg/kg groups, respectively. SIVD: Subcortical ischemic vascular dementia; MBP: myelin basic protein; FITC: fluorescein isothiocyanate.