Fig. 3.

a-c Posterior cortical DA, 5HT and NE (mean ± sem) for each sex, percent of WT Cu0 control mean. In the posterior cortex there was a significant (p < 0.0005) main effect of MTKO increasing 5HT levels relative to WT mice. Number of rats/condition: Wildtype Cu0 males = 16, Wildtype Cu0 females = 13; Wildtype Cu10 males = 23; Wildtype Cu10 females = 13; MTKO Cu0 males = 11; MTKO Cu0 females = 19; MTKO Cu10 males = 10; MTKO Cu10 females = 15. d 5HT turnover was significantly (p < 0.05) higher in females than males