(A) Rats that received a combination of reaching and exercise (#CCI + RE) or reaching, exercise, and constraint (*CCI + REC) showed enhanced reaching behaviors compared with injured animals without rehabilitation (#P < .05, *P < .01). (B) Injured animals without rehabilitation (CCI) showed progressively more abnormal reaching behaviors over time, whereas all rehabilitation strategies reduced abnormal compensatory reaching behaviors compared with CCI: §CCI + R (P < .0001); ŦCCI + C (P < .0001); #CCI + RE (P < .01); and *CCI + REC (P < .0001).
Abbreviation: CCI, controlled cortical impact.