Table 2.
AE model for shared genetic determination (pleiotropy) rG between hepatic steatosis, fibrosis, and metabolic risk factors
| Hepatic Steatosis (MRI-PDFF) | Hepatic Fibrosis (MRE) | |||
|---|---|---|---|---|
|
| ||||
| Trait | rG estimate (CIs) | P-value | rG estimate (CIs) | P-value |
|
| ||||
| BMI | 0.534 (0.305, 0.713) | 3.19e-5 | 0.493 (0.493, 0.845) | 0.00649 |
|
| ||||
| Blood pressure* | ||||
| Systolic | 0.360 (0.052, 0.636) | 0.023 | 0.308 (−0.137, 0.688) | 0.160 |
| Diastolic | 0.444 (0.444, 0.742) | 0.0071 | 0.257 (0.257, 0.723) | 0.292 |
|
| ||||
| Total cholesterol | −0.021 (−0.397, −0.014) | 0.903 | −0.299 (−0.839, 0.218) | 0.243 |
|
| ||||
| LDL-cholesterol | 0.076 (−0.134, 0.090) | 0.658 | −0.127 (−0.609, −0.053) | 0.600 |
|
| ||||
| HDL-cholesterol | −0.451 (−0.643, −0.216) | 3.57e-4 | −0.614 (−0.890, −0.614) | 5.74e-4 |
|
| ||||
| Triglycerides | 0.678 (0.585, 0.830) | 4.69e-8 | 0.657 (0.657, 1) | 3.44e-4 |
|
| ||||
| Ferritin | 0.370 (−1, 1) | 0.445 | 1 (−1, 1) | 0.057 |
|
| ||||
| Glucose | 0.716 (0.716, 1) | 1.64e-4 | 0.746 (0.746, 1) | 0.0029 |
|
| ||||
| HOMA-IR | 0.490 (0.212, 0.739) | 8.71e-4 | 0.610 (0.218, 1) | 0.0025 |
|
| ||||
| Insulin | 0.289 (0.017, 0.531) | 0.038 | 0.429 (0.167, 0.735) | 0.023 |
|
| ||||
| HbA1c | 0.588 (0.588, 1) | 9.83e-4 | 0.566 (0.566, 1) | 0.015 |
|
| ||||
| Liver fibrosis (MRE) | 0.756 (0.716, 1) | 2.54e-5 | N/A | N/A |
Significant (p<0.05) coefficients are designated in bold type. rG indicates genetic co-variance that detects the shared genetic determination between two traits.
Abbreviations: MRI-PDFF, magnetic resonance imaging-proton density fat fraction; MRE, magnetic resonance elastography; BMI, body mass index; CI: confidence interval; LDL, low-density lipoprotein; HDL, high-density lipoprotein; HOMA-IR, homeostatic model assessment of insulin resistance; HbA1c, hemoglobin A1c.