Fig. 1.

Schematic of I-TASSER modeled hVDAC-2 WT barrel showing the side (left panel) and top view (right panel). The barrel (shown as blue cartoon) highlights the positions of the four tryptophans (red sticks) with respect to the bilayer membrane (grey spheres in the left panel). Of the four intrinsic tryptophans, three (Trp-75, Trp-160 and Trp-221) lie close to the interface, while Trp-86 lies towards the interior. The position of the bilayer membrane was defined by superposing the hVDAC-2 structure on the zebrafish VDAC-2 structure (PDB ID: 4BUM) obtained from the OPM database [27], [28]. IMS, intermembrane space.