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. 2016 Nov 2;10:540. doi: 10.3389/fnhum.2016.00540

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Copyright © 2016 Chen, Chen, Xia, Wu, Chen, He, Xue, Wang, He and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of COMT and BDNF on mean ReHo of each ROI (N = 298). (A) right medial frontal gyrus (rMeFG); (B) left superior frontal gyrus (lSFG); (C) right superior and medial frontal gyrus (rSMFG); (D) right medial orbitofrontal gyrus (rMOFG); (E) right middle frontal gyrus (rMFG). For all five regions of interest (ROIs), each of the middle two groups (i.e., with presumed medium level of dopamine signaling) showed significantly lower ReHo than each of the other two groups (i.e., low or high level of dopamine signaling; p < 0.05). Details on additional significant contrasts are available from the authors.