Table 2.
Brain areas showing significant COMT and BDNF gene interaction effects on ReHo with age, gender, and IQ as covariates, with AlphaSim correction (p < 0.01; N = 298).
| Brain areas | Cluster size (Voxels) | Brodmann areas (BA) | Peak coordinates in MNI | T-value | p-value (uncorrected) | ROI | ||
|---|---|---|---|---|---|---|---|---|
| x | y | z | ||||||
| Left medial frontal gyrus(rMeFG) | 85 | 9/10 | −9 | 54 | 12 | 3.84 | 0.000 | 1 |
| left superior frontal gyrus(lSFG) | 46 | 47 | −30 | 42 | 6 | 3.61 | 0.000 | 2 |
| −39 | 45 | −9 | 3.40 | 0.000 | ||||
| −30 | 42 | −3 | 3.28 | 0.001 | ||||
| Right superior and medial frontal gyrus(rSMFG) | 40 | 9/10 | 6 | 51 | 21 | 3.53 | 0.000 | 3 |
| 12 | 45 | 27 | 3.01 | 0.001 | ||||
| Right medial orbitofrontal gyrus(rMOFG) | 25 | 10/11 | 6 | 51 | −6 | 3.30 | 0.001 | 4 |
| 12 | 42 | −6 | 2.63 | 0.004 | ||||
| Right middle frontal gyrus(rMFG) | 24 | 6 | 48 | 0 | 48 | 3.25 | 0.001 | 5 |
| 36 | 6 | 48 | 3.03 | 0.001 | ||||
| Right paracentral lobule | 64 | 4/5/6 | −3 | −24 | 63 | 3.02 | 0.001 | |
| 6 | −36 | 69 | 2.79 | 0.003 | ||||
| 3 | −30 | 57 | 2.66 | 0.004 | ||||
| Right middle frontal gyrus(rMFG) | 54 | 24 | 27 | 9 | 3.64 | 0.000 | ||
| 27 | 33 | 0 | 3.33 | 0.000 | ||||
| 45 | 39 | 0 | 2.66 | 0.004 | ||||
| Left insula | 47 | −27 | −27 | 24 | 3.90 | 0.000 | ||
| −30 | −36 | 33 | 3.24 | 0.001 | ||||
| Right middle occipital gyrus(rMOG) | 39 | 19/39 | 33 | −75 | 24 | 3.82 | 0.000 | |
| Left superior occipital gyrus(SOG) | 38 | 18/19 | −12 | −84 | 21 | 3.25 | 0.001 | |
| −18 | −87 | 27 | 2.78 | 0.003 | ||||
| Right corpus callosum | 38 | 30 | 15 | 27 | 3.58 | 0.000 | ||
| 12 | 15 | 24 | 2.92 | 0.002 | ||||
| 21 | 12 | 27 | 2.72 | 0.003 | ||||
| Lingual gyrus | 36 | 18/19 | −33 | −72 | −6 | 4.12 | 0.000 | |
| −18 | −72 | −6 | 2.95 | 0.002 | ||||
| Right paraHippocampal gyrus | 34 | 28/35 | 18 | −24 | −24 | 3.97 | 0.000 | |
| Right superior motor areas | 30 | 6/8/32 | 15 | 9 | 57 | 3.38 | 0.000 | |
| 9 | 18 | 45 | 3.13 | 0.001 | ||||
| Left superior temporal gyrus(lSTG) | 28 | −42 | −33 | 3 | 3.59 | 0.000 | ||
| −36 | −39 | 9 | 2.68 | 0.004 | ||||
| Right precentral gyrus | 27 | 21 | −6 | 51 | 3.60 | 0.000 | ||
| 36 | 0 | 33 | 3.24 | 0.001 | ||||
| Left lentiform nucleus | 26 | 10 | −6 | −3 | −3 | 4.58 | 0.000 | |
| Undefined | 24 | 3 | −27 | −57 | 3.08 | 0.001 | ||
| Right superior temporal gyrus(lSTG) | 22 | 39 | 45 | −54 | 18 | 3.76 | 0.000 | |
| Right inferior parietal lobule | 21 | 40 | 45 | −36 | 51 | 2.77 | 0.003 | |
| 45 | −33 | 36 | 2.70 | 0.004 | ||||
| Right parahippocampal gyrus | 20 | 28 | 12 | 18 | −30 | 2.99 | 0.002 | |
| 15 | 3 | −33 | 2.45 | 0.007 | ||||
| Right precuneus | 20 | 7 | 3 | −78 | 42 | 3.71 | 0.000 | |
| Left postcentral gyrus | 20 | 4/6 | −54 | −6 | 48 | 3.29 | 0.001 | |
| Cerebellum anterior lobe | 18 | 30 | −48 | −24 | 3.80 | 0.000 | ||
| Left corpus callosum | 18 | −3 | 21 | 3 | 3.98 | 0.000 | ||
| Undefined | 17 | −48 | −12 | −45 | 3.42 | 0.000 | ||
| −42 | −6 | 51 | 3.08 | 0.001 | ||||