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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: J Thromb Haemost. 2016 May 10;14(7):1337–1349. doi: 10.1111/jth.13327

Figure 2. Distinct differences in clinical and basic research studies assessing anticoagulant intervention in liver fibrosis/cirrhosis.

Figure 2

Whereas the majority of anticoagulant trials in patients have been performed in patients with established liver disease/cirrhosis, few if any animal studies have addressed the impact of anticoagulants or genetic interventions on established liver fibrosis or severe cirrhosis. Rather, these studies address the role of hemostasis during the earliest phase of disease development. From a translational standpoint, it is important that this distinction be considered.