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Cerebellar GNPs proliferate extensively after deletion of Ptch1; however, the majority of Ptch1-deficient GNPs finally exits the cell cycle and differentiates into mature neurons. During the initial proliferation, a proportion of Ptch1-deficient GNPs expresses Nestin, which further promotes the proliferation of GNPs and allows them to accumulate oncogenic alterations necessary for MB tumorigenesis.
