Fig. 3.

Regulation of a TSHα promoter by TR isoforms and mutated protein versions in response to T₃. A TSHα promoter luciferase reporter was transfected together with TRα wild-type (wt) or the indicated mutants thereof (a), or together with TRβ wild-type and mutated versions (b) into HepG2 cells and subsequently stimulated with T₃. Expression rates are illustrated relative to those of the corresponding wild-type TR isoform without T₃ stimulation ± SD. * Indicates p < 0.05 relative to wild-type and unstimulated and ^# indicates p < 0.05 relative to wild-type and stimulated levels.