Table 1.
Characteristics of the control group and untreated patients with thyroid autoimmune disease
| Parameter | Control group |
TAD |
p value2 | |
|---|---|---|---|---|
| mean (SD) or median [IQR]1 (n = 271) | 95% CI1 | mean (SD) or median [IQR] (n = 86) | ||
| Gender (female/male), n | 201 (75%)/67 (25%) | – | 76 (88%)/10 (12%) | 0.01 |
| Age, years | 46.5 (16.7) | – | 44.6 (16.8) | 0.35 |
| BMI, kg/m2 | 26.1 (4.55) | – | 26.2 (5.15) | 0.82 |
| Thyroid volume, ml | 12.1 (4.30) | – | 12.1 (6.20) | 0.96 |
| FT4, pmol/l | 14.2 (1.59) | 11.06–17.31 | 13.7 (2.04) | 0.04 |
| FT3, pmol/l | 5.04 (0.54) | 4.14–5.94 | 4.95 (0.62) | 0.25 |
| TSH, mIU/l | 1.49 [1.00; 2.05] | 0.47–3.77 | 2.97 [1.72; 4.48] | <0.001 |
| lnTSH, mIU/l | 0.37 (0.52) | – | 1.06 (0.70) | <0.001 |
| TPO Ab, IU/l | – | 728 [106; 1,300] | – | |
| FT3-FT4 ratio | 0.36 (0.05) | 0.27–0.45 | 0.37 (0.06) | 0.20 |
| Deiodinase activity, nmol/s | 33.1 (4.58) | 24.6–41.9 | 34.0 (5.48) | 0.20 |
| FT4-TSH ratio | 9.31 [6.87; 14.3] | 3.4–30.9 | 4.81 [2.97; 7.62] | <0.001 |
| Thyroid capacity, pmol/s Specific thyroid capacity, | 3.43 (1.37) | 1.67–7.51 | 2.34 (1.20) | <0.001 |
| pmol/s/ml volume | 0.31 (0.15) | 0.13–0.66 | 0.23 (0.14) | <0.001 |
IQR = Interquartile range; – = not applicable; TAD = thyroid autoimmune disease.
1
After removal of three outliers.
2
Compared to the control group.