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Vasoconstriction effects of 20-HETE in the absence or presence of TP receptor antagonist. A, Representative tracing of 20-HETE (10−5.4 M) constriction of mouse aortic ring ± TP receptor antagonist (SQ29548, 100 nM). B, AUC analysis of 20-HETE constriction ± TP receptor antagonist (SQ29548). Data are shown as mean ± SEM, n = 3/group and were analyzed by t-test. *** P < .0001. 20-HETE, 20-hydroxyeicosatrienoic acid.
