Effects of TCDD and an n-3 PUFA diet on mRNA expression of Cyp1a1 and Cyp1b1. A–E, mRNA expression of Cyp1a1 and Cyp1b1, normalized to normalized to the housekeeping gene, RNA polymerase 2 (Pol2), in liver, kidney, aorta, heart, and lung. Data were analyzed by 2-way ANOVA with post hoc Holm-Sidak comparisons. *Above a horizontal line, indicates a statistically significant difference between chow and n-3 diet, P < .05. *Above a vertical bar indicates a significant difference between control and TCDD treatment groups within the same diet, ** P < .01, *** P < .001. #Above a vertical bar indicates difference between chow and n-3 PUFA diets within the same treatment group, #P < .05, ##P < .01, ###P < .001.