Table 3.

DTG Concentrations in BP and SP^a

Patient	DTG in BP, ng/mL			DTG Free Fraction in BP, %	DTG in SP, ng/mL			DTG Free Fraction in SP, %	SP/BP Ratio, %
	Week 4	Week 24	Mean		Week 4	Week 24	Mean		Week 4	Week 24	Mean
1	2290	924	1607	0.441	171	67.2	119.1	52.8	7.47	7.27	7.37
2	124	353	238.5	NA	15.7	38.8	27.25	34.7	12.66	10.99	11.83
3	1710	2230	1970	0.557	137	152	144.5	50.8	8.02	6.81	7.41
4	1330	2000	1665	0.457	141	207	174	42.6	10.60	10.35	10.47
5	1460	1750	1605	0.412	92.6	164	128.3	34.2	6.342	9.37	7.86
6	1340	3100	2220	NA	92.5	264	178.25	NA	6.90	8.51	7.71
7	1200	1480	1340	NA	92.2	129	110.6	NA	7.68	8.71	8.19
8	1390	2450	1920	0.415	331	423	377	48.0	23.81	17.26	20.54
9	864	1420	1142	0.439	23.9	64.5	44.2	42.4	2.77	4.54	3.65
10	1100	829	964.5	0.470	160	182	171	51.9	14.5	21.95	18.25
11	1050	1990	1520	0.447	88.5	233	160.75	48.6	8.43	11.71	10.07
12	838	1290	1064	0.455	32.1	111	71.55	51.5	3.83	8.60	6.22
13	677	627	652	0.481	33	47	40	59.7	4.87	7.49	6.18
14	805	1010	907.5	0.387	60.9	72.9	66.9	38.6	7.56	7.22	7.39
15	1200	1060	1130	0.459	70.2	104	87.1	47.1	5.85	9.81	7.83
Median	1200	1420	1340	0.455	92.2	129	119.1	48	7.56	8.71	7.83

Abbreviations: BP, blood plasma; DTG, dolutegravir; NA, not available; SP, seminal plasma.

^a DTG concentrations at the end of the dosing interval (24 hours).