Figure 3.

Positive (blue) and negative (tan) predictive values for resistance to the ESCs, azithromycin, and ciprofloxacin as determined in the dataset of 1102 gonococcal genomes. Two MIC thresholds are presented for the ESCs, representing the current threshold for reduced susceptibility and one dilution lower. Azithromycin reduced susceptibility is defined by MIC ≥ 1µg/mL for isolates between 2000-2004 and ≥ 2µg/mL starting in 2005, due to a change in the media used for agar dilution testing (see Supplemental Methods). Abbreviations: CFX, cefixime; CRO, ceftriaxone; ESC, extended-spectrum cephalosporin; MIC, minimum inhibitory concentration; rRNA, ribosomal RNA.