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. 2016 Sep 16;214(10):1579–1587. doi: 10.1093/infdis/jiw420

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© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — A, Maximum likelihood whole-genome-sequence phylogeny of 1102 Neisseria gonorrhoeae isolates, based on single-nucleotide polymorphisms from mapping to the FA1090 reference genome, with the inner annotation rings representing amino acid residues at ParC-87, GyrA-91, and GyrA-95. The outer annotation rings represent ciprofloxacin (Cipro) minimum inhibitory concentrations (MICs) and dichotomized resistance (R) and susceptibility (S; cutoff for resistance at 1 µg/mL). The asterisks indicate quinolone-resistant N. gonorrhoeae that lack the ParC-87, GyrA-91, and GyrA-95 variants. B, Histograms of Cipro MICs of isolates based on haplotypes at ParC-87, GyrA-91, and GyrA-95 in absolute frequency (upper histogram) and in fraction (lower histogram).

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