Table 1.
Patient no. | WHO subtype | Clonal chromosomal abnormalities detected | IPSS‐R Risk group | CD34+CD38−CLEC12A+/ CD34+CD38− | AML‐free survival (d) |
---|---|---|---|---|---|
1 | RAEB‐1 | No aberrations | LOW | 0% | |
2 | RAEB‐1 | No aberrations | INT | 0% | 605 |
3 | RCMD | No aberrations | V‐LOW | 0% | |
4 | RCUD | +8 | LOW | 37·9% | 1169 |
5 | RAEB‐1 | inv(3)(p12q26) | V‐HIGH | 6·3% | 583 |
6 | RAEB‐1 | No aberrations | INT | 56·7% | 16 |
7 | RCUD | Complex | INT | 0% | |
8 | RAEB‐1 | +del(1)(p13), +8 | INT | 1·5% | 658 |
9 | RCUD | No aberrations | V‐LOW | 17·4% | 154 |
10 | NAa | ND | NA | 1·8% | 713 |
11 | Hypo RCUD | No aberrations | LOW | 4·1% | 91 |
12 | RAEB‐1 | No aberrations | HIGH | 0% | |
13 | RAEB‐1 | No aberrations | INT | 6·4% | |
14 | RCUD | ‐X | INT | 22·6% | |
15 | RCUD | No aberrations | LOW | 11·6% | |
16 | RCUD | No aberrations | V‐LOW | 14·7% | |
17 | RARS | No aberrations | LOW | 0% | |
18 | MDS‐U | No aberrations | LOW | 3·2% | 210 |
19 | RAEB‐2 | No aberrations | HIGH | 4·3% | |
20 | RCUD | del(15)(q22q26) | HIGH | 5·6% | |
21 | RAEB‐2 | Complex, incl. del(5q)(q13q33),‐7 | V‐HIGH | 0·6% | 55 |
22 | RCUD | ‐7 | INT | 5·6% | |
23 | RCUD | No aberrations | LOW | 1·2% | |
24 | RCUD | No aberrations | V‐LOW | 6·8% | 405 |
25 | MDS‐U | +mar | LOW | 0% | 670 |
26 | RCUD | No aberrations | INT | 0% | 554 |
27 | RCUD | ‐Y | V‐LOW | 0% | |
28 | RCUD | No aberrations | V‐LOW | 7·4% | |
29 | RCUD | +8 | INT | 12·0% | 482 |
30 | RCMD | Complex, incl. ‐5, ‐7 | NAa | 17·4% | |
31 | Del(5q) | del(5)(q13q31) | INT | 0·1% |
AML, acute myeloid leukaemia; INT, intermediate; IPSS‐R, Revised International Prognostic Scoring System; MDS‐U, myelodysplastic syndrome – unclassified; NA, not applicable; ND, not done; RAEB‐1, refractory anaemia with excess blasts type 1; RAEB‐2, refractory anaemia with excess blasts type 2; RARS, refractory anaemia with ringed sideroblasts; RCMD, refractory cytopenia with multilineage dysplasia; RCUD, refractory cytopenia with unilineage dysplasia; V‐HIGH, Very High; V‐LOW, Very Low; WHO, World Health Organization.
Insufficient material for complete morphological evaluation.