Table 1.
Association of FOXO3A and the shared epitope with radiologic measures of disease outcome in patients with rheumatoid arthritisa
| Shared epitope | FOXO3A (rs12212067) | |||
|---|---|---|---|---|
| Effect size (95% CI) | P | Effect size (95% CI) | P | |
| Larsen score | ||||
| Unadjusted | 1.42 (0.50, 2.34) | 0.0013 | −1.50 (−2.73, −0.26) | 0.0089 |
| Adjusted for the shared epitope | – | – | −1.88 (−3.15, −0.60) | 0.0020 |
| Adjusted for treatment | – | – | −1.50 (−2.75, −0.25) | 0.0094 |
| Modified Larsen score | 1.51 (0.66, 2.35) | 0.00024 | −1.65 (−2.80, −0.50) | 0.0025 |
| No. of eroded joints | 0.36 (0.17, 0.54) | 0.00012 | −0.29 (−0.53, −0.06) | 0.0073 |
a
Effect size represents the change in Larsen score units or in the number of eroded joints. The modified Larsen score was obtained by recalculating the Larsen score using the presence of joint space narrowing (in the absence of any other modification) as 0 instead of 1, in order to reduce potential misclassification due to osteoarthritis. 95% CI = 95% confidence interval.