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. 2016 Nov 2;12(11):e1005996. doi: 10.1371/journal.ppat.1005996

Fig 1. CC(032x013)F1 WNV-infected mice maintain a chronic WNV infection, with virus persisting in the CNS at d60.

Fig 1

Cohorts of mice were infected with 100pfu WNV. (A) Compared to the B6 model of infection, CC(032x013)F1 mice do not return to and exceed starting weight by d25 p.i., but maintain weight loss out to d60. (B) PCR for WNV in brain at indicated time points. Results are from two separate experiments: the discovery screen, which included d7, d12, d21, and d28 time points, and validation mice, which included d28 and d60 endpoints. Results were comparable for overlapping endpoints. Viral RNA was detected in the brains of 66% of d28 and 20% of d60 mice, for both CC(032x013)F1 and B6 mice. (C) Spleen WNV-specific and (D) Brain WNV-specific CD8+ T cells in B6 and CC(032x013)F1 mice at corresponding time points. The discovery screen included three mice per time point (d7, 12, 21, and 28) and the validation experiments included six mice per time point.