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. 2016 Nov 2;11(11):e0165629. doi: 10.1371/journal.pone.0165629

Table 1. Summary results of meta-analysis and indirect treatment comparison.

Variable a Comparison Type Group Results [Mean difference (95%CI)] P values
HbA1c, %
Meta-analysis Dapagliflozin vs. Placebo –0.82 [–0.95, –0.68] < 0.00001
Meta-analysis Acarbose vs. Placebo –0.47 [–0.86, –0.07] 0.02
ITC Dapagliflozin vs. Acarbose –0.35 [–0.767, 0.067] 0.45572
SBP, mmHg
Meta-analysis Dapagliflozin vs. Placebo –4.30 [–6.94, –1.67] 0.001
Meta-analysis Acarbose vs. Placebo –0.17 [–4.51, 4.17] 0.94
ITC Dapagliflozin vs. Acarbose –4.13 [–9.207, 0.947] --
Body Weight, kg
Meta-analysis Dapagliflozin vs. Placebo –1.91 [–2.31, –1.50] < 0.00001
Meta-analysis Acarbose vs. Placebo –1.41 [–2.63, –0.18] 0.02
ITC Dapagliflozin vs. Acarbose –0.50 [–1.79, 0.79] 0.79383

HbA1c, glycated hemoglobin; ITC, indirect treatment comparison; SBP, systolic blood pressure.

a Variables were taken from data of 4 included placebo-controlled studies [4142,5556].