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Inhibition of DNA methylation increases cisplatin and etoposide sensitivity of PC3 cells. The cells were exposed to AzaC (3 μM) for 24 h. EndoG mRNA induction was confirmed by real time RT-PCR (in Figure 6C above). The cells were then exposed to cisplatin (60 μM, 24 h) or etoposide (100 μM, 24 h). Cell death was measured by the LDH release. n=4 per group, *p<0.05 compared to corresponding non-treated cells.
