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. 2004 Jul 12;101(31):11178–11192. doi: 10.1073/pnas.0403600101

Table 3. Potential drug targets: Selected poxvirus enzymes.

Drug target Poxvirus enzymes
DNA replication and recombination (Fig. 2, steps 6 and 7)
E9 DNA polymerase (target of cidofovir)
A20 Polymerase processivity factor
A22 Holliday junction resolvase
D4 Uracil DNA glycosylase
D5 Nucleoside triphosphatase
mRNA synthesis and modification (Fig. 2, steps 2, 8, and 10)
Nine subunits RNA polymerase (J6, A24, A29, E4, J4, A5, D7, G5.5, and H4)
E1 (+J3) Poly(A) polymerase [catalytic (+stimulatory)]
D1 (+D12) mRNA capping enzyme [catalytic (+stimulatory)]
H6 Topoisomerase I
H1 Protein phosphatase (dual specificity)
Protein modification and virus assembly (Fig. 2, step 14)
F10 Protein kinase (dual specificity)
I7 Cysteine protease
E10, A2.5, G4 Thiol oxidases