Figure 3.

129SvEv Mice: subchronic and chronic treatment effect on feeding latency in novelty suppressed feeding (NSF). (A-B) Following a subchronic, 8-day treatment, a response was observed in mice treated with vilazodone 10mg/kg as evidenced by lower latency to feed relative to vehicle-treated controls in the NSF test. Fluoxetine did not significantly affect latency to feed in this test (n = 15 mice/group). (C-D) A robust response was also observed in mice following chronic, 28-day treatments with vilazodone 3 and 10mg/kg relative to vehicle-treated controls in the NSF test. The difference in latency elicited by chronic fluoxetine administration at 20mg/kg was not significant (n = 15 mice/group). (A-D) Kaplan-Meier cumulative survival curve. (B-D) Scatter graph depicting individual animal latencies with mean and SEM (*P<.05 vs vehicle; **P<.01 vs vehicle).