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| Genotype | n | Litters | Pups | Pups per litter | Litters per female |
|---|---|---|---|---|---|
| AR+/+ | 8 | 26 | 255 | 9.8 ± 2.5 | 3.3 ± 0.5 |
| AR+/- | 8 | 25 | 201 | 8.0 ± 2.4* | 3.1 ± 0.8 |
| AR-/- | 8 | 18 | 81 | 4.5 ± 2.5‡ | 2.3 ± 0.7§ |
Known fertile males were bred with 10- to 11-week-old female liittermates for 12 weeks. Results are presented as mean ± SD. *, P = 0.012 vs. AR+/+, Student's unpaired t test; ‡, P < 0.0001 vs. AR+/+, Student's unpaired t test; §, P = 0.0058 vs. AR+/+, Student's unpaired t test.
