Fig. 1.

Chemical synthesis of the photoactivatable organotin derivative 7(DDBT-Cl). Dibutylphenyltin iodide 3 was prepared as described in the literature by Grignard reaction and subsequent halogenation. Synthesis of 4 was obtained after conversion with Simmons–Smith reagent ICH₂ZnI, which was further coupled to an aryldiazirinylmethyl alcohol 5 in the presence of sodium hydride and hexamethylphosphoramide (HMPA). Deprotection of the product 6 was obtained after stoichiometric treatment with iodine monochloride in carbon tetrachloride.