Table 4.
pQCT Tibia Bone Variables’ Association With Fragility Fractures
| Bone variable | Unadjusted
|
Age-adjusted
|
||||
|---|---|---|---|---|---|---|
| OR (CI) per SD | OR (CI) per LSC | OR (CI) per SEE | OR (CI) per SD | OR (CI) per LSC | OR (CI) per SEE | |
| BV/TV (fraction) | 0.94 (0.55, 1.60) | 0.97 (0.78, 1.22) | 0.99 (0.91, 1.07) | 0.88 (0.50, 1.54) | 0.95 (0.75, 1.20) | 0.98 (0.90, 1.07) |
| Tb.Sp (mm) | 1.10 (0.63, 1.90) | 1.03 (0.85, 1.26) | 1.01 (0.96, 1.06) | 0.98 (0.55, 1.77) | 1.00 (0.81, 1.23) | 1.00 (0.94, 1.06) |
| Tb.Sp MI (mm) | 1.10 (0.63, 1.90) | 1.03 (0.85, 1.26) | 1.01 (0.96, 1.06) | 0.98 (0.55, 1.77) | 0.99 (0.80, 1.23) | 1.00 (0.94, 1.06) |
| Tb.Th (mm) | 0.79 (0.46, 1.36) | 0.84 (0.56, 1.26) | 0.93 (0.79, 1.10) | 0.78 (0.44, 1.37) | 0.83 (0.55, 1.26) | 0.93 (0.78, 1.10) |
| Tb.Th MI (mm) | 0.79 (0.46, 1.36) | 0.84 (0.56, 1.26) | 0.93 (0.79, 1.10) | 0.78 (0.44, 1.37) | 0.83 (0.55, 1.26) | 0.93 (0.78, 1.10) |
| Tb.N (no./mm) | 1.20 (0.69, 2.09) | 1.08 (0.85, 1.39) | 1.03 (0.95, 1.12) | 1.11 (0.61, 2.02) | 1.05 (0.80, 1.37) | 1.02 (0.93, 1.11) |
| Ct.Th (mm) | 1.24 (0.72, 2.13) | 1.23 (0.73, 2.10) | 1.12 (0.84, 1.48) | 1.15 (0.65, 2.04) | 1.15 (0.66, 2.01) | 1.08 (0.80, 1.45) |
| vBMDi (mg/cm3) | 1.29 (0.74, 2.24) | 1.13 (0.86, 1.49) | 1.06 (0.94, 1.20) | 1.15 (0.64, 2.06) | 1.07 (0.80, 1.43) | 1.03 (0.91, 1.18) |
| vBMDc (mg/cm3) | 1.72 (0.94, 3.14) | 1.36 (0.96, 1.92) | 1.16 (0.98, 1.38) | 1.49 (0.78, 2.85) | 1.26 (0.87, 1.82) | 1.12 (0.93, 1.34) |
| vBMDtr (mg/cm3) | 0.69 (0.39, 1.22) | 0.82 (0.60, 1.11) | 0.90 (0.76, 1.06) | 0.67 (0.37, 1.21) | 0.81 (0.59, 1.11) | 0.89 (0.75, 1.06) |
Note: Magnitude of odds for fragility fractures associated with each SD, LSC, or SEE increase (+) or decrease (−) in tibia bone variables obtained on pQCT was determined with a binary logistic regression model. Models were examined with and without adjusting for age. CI = 95% CI (lower, upper).
Abbr: Ct.Th, cortical thickness; BV/TV, bone volume/total volume; CI, confidence interval; LSC, least significant change; MI, Model-Indpendent; OR, odds ratio; pQCT, peripheral quantitative computed tomography; SD, standard deviation; SEE, standard error of the estimate; Tb.N, trabecular number; Tb.Sp, trabecular spacing; Tb.Th, trabecular thickness; vBMDc, cortical volumetric bone mineral density; vBMDi, integral volumetric bone mineral density; vBMDtr, trabecular volumetric bone mineral density.