Table 6.
Changes in Bone Variables Required to Yield 50% Increase in Odds for Fractures
| Modality | Radius bone outcome | OR (95% CI) | Difference in bone outcome |
|---|---|---|---|
| HR-pQCT | Ct.Th | 1.50 (1.05, 2.14) | −0.114 mm |
| pQCT | Ct.Th | 1.50 (0.40, 5.66) | −0.301 mm |
| HR-pQCT | vBMDc | 1.50 (1.04, 2.16) | −42.50 mg/cm3 |
| pQCT | vBMDc | 1.50 (0.20, 11.52) | −440.72 mg/cm3 |
| Age-adjusted values | |||
| HR-pQCT | Ct.Th | 1.50 (1.00, 2.25) | −0.126 mm |
| pQCT | Ct.Th | 1.50 (0.02, 132.07) | −0.956 mm |
| HR-pQCT | vBMDc | 1.50 (0.98, 2.30) | −47.70 mg/cm3 |
| pQCT | vBMDc | 1.50 (0.00, +N) | — |
|
| |||
| Modality | Tibia bone outcome | OR (95% CI) | Difference in bone outcome |
|
| |||
| HR-pQCT | Ct.Th | 1.50 (1.00, 2.26) | −0.228 mm |
| pQCT | Ct.Th | 1.50 (0.54, 4.17) | −0.327 mm |
| HR-pQCT | vBMDc | 1.50 (1.05, 2.14) | −38.99 mg/cm3 |
| pQCT | vBMDc | 1.50 (0.95, 2.36) | −81.91 mg/cm3 |
| Age-adjusted values | |||
| HR-pQCT | Ct.Th | 1.50 (0.91, 2.47) | −0.265 mm |
| pQCT | Ct.Th | 1.50 (0.30, 7.52) | −0.490 mm |
| HR-pQCT | vBMDc | 1.50 (1.00, 2.26) | −41.76 mg/cm3 |
| pQCT | vBMDc | 1.50 (0.78, 2.88) | −110.48 mg/cm3 |
Note: Logistic regression equations were used to extrapolate the magnitude of difference in Ct.Th and cortical vBMD required to yield an OR of 1.50 at the 95% confidence level for both pQCT and HR-pQCT. Values were reported separately for bone outcomes derived from the radius and tibia as well as with and without adjustment for age. Bold indicates variables that were significant at the 95% confidence level in binary logistic regression models. The symbol “—” indicates estimates that were not generated because of infinite CIs around the OR.
Abbr: CI, confidence interval; OR, odds ratio; Ct.Th, cortical thickness; HR-pQCT, high-resolution peripheral quantitative computed tomography; vBMDc, cortical volumetric bone mineral density.