Table 2.
Genotype frequency and association analysis of CH25H tSNPs in MS patients (MS), patients with relapsing remitting (RR) disease at onset, and patient with primary progressive (PP) disease at onset.
| dbSNP | Genotypes | Groups | n (%) | p-value | ||
|---|---|---|---|---|---|---|
| rs10749599 | GG/GT/TT | Control | 328 (0.37) | 394 (0.45) | 155 (0.17) | |
| MS | 810 (0.37) | 1000 (0.45) | 389 (0.18) | 0.757 | ||
| RR | 475 (0.36) | 610 (0.46) | 234 (0.18) | 0.488 | ||
| PP | 168 (0.39) | 196 (0.45) | 68 (0.16) | 0.366 | ||
|
| ||||||
| rs17382301 | GG/GA/AA | Control | 668 (0.76) | 193 (0.22) | 18 (0.02) | |
| MS | 1623 (0.74) | 537 (0.24) | 39 (0.02) | 0.132 | ||
| RR | 978 (0.74) | 317 (0.24) | 25 (0.02) | 0.257 | ||
| PP | 312 (0.72) | 115 (0.27) | 6 (0.01) | 0.048 | ||
|
| ||||||
| rs4417181 | TT/TC/CC | Control | 662 (0.76) | 201 (0.23) | 10 (0.01) | |
| MS | 1697 (0.78) | 435 (0.20) | 40 (0.02) | 0.026 | ||
| RR | 1011 (0.78) | 269 (0.21) | 21 (0.02) | 0.123 | ||
| PP | 343 (0.80) | 77 (0.18) | 9 (0.02) | 0.015 | ||
|
| ||||||
| rs4933497 | AA/AG/GG | Control | 463 (0.53) | 347 (0.40) | 63 (0.07) | |
| MS | 1128 (0.52) | 891 (0.41) | 170 (0.08) | 0.416 | ||
| RR | 688 (0.52) | 524 (0.40) | 102 (0.08) | 0.614 | ||
| PP | 208 (0.48) | 188 (0.44) | 35 (0.08) | 0.104 | ||