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The ram gene cluster and sequence analysis of ramC.(A) The arrangement of the five genes in the ram cluster of S. coelicolor.(B) Amino acid alignment of the C terminus of RamC of S. coelicolor with the C termini of the lantibiotic modification enzymes CinM and MrsM, from Streptomyces cinnamoneus and Bacillus spp., respectively. Dashed lines indicate conserved sequences commonly found in Lan cyclases.
