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In vivo inhibition of tumor growth by compound 27. 27 inhibits tumor growth in MV4;11 subcutaneous model of MLL leukemia developed in CB17 SCID mice after injecting 0.5 × 107 MV4;11 cells, n = 9 per group. Mice were treated once daily with 27 (45 mg/kg) or vehicle via ip, resulting in substantial reduction of the tumor volume (p < 0.001). Error bars represent SEM.
