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. Author manuscript; available in PMC: 2016 Nov 2.
Published in final edited form as: J Med Chem. 2016 Jan 25;59(3):892–913. doi: 10.1021/acs.jmedchem.5b01305

Scheme 3. Synthesis of Compound 2a.

Scheme 3

aReagents and conditions: (i) TrCl, DMAP, Et3N, DCM, rt, 24 h, 96%; (ii) 41a, NaH, DMF, rt to 60 °C, overnight, 81%; (iii) NBS, AIBN, CCl4, reflux, 2 h; (iv) 39, DIEA, DCM, 5 h; (v) HCl, MeOH, rt, 1 h, 42% (3 steps).