Table 4.

PK Parameters for Menin–MLL Inhibitors^a

compd	route of admin	dose (mg/kg)	Tmax (h)	Cmax (ng/ml)	AUCobs (h·ng/mL)	T1/2 (h)	Clobs (mL min−1 kg−1)	Vss (mL/kg)	F (%)
1b	iv	15			6576	3.1	38.1	6516
	po	30	1	1516	7509	3.1			57
20b	iv	15			5666	1.7	44.1	4454
	po	30	2	649	3846	4			34
21b	iv	15			9397	1.8	26.6	3698
	po	30	0.5	2113	8717	2			46
27b	iv	15			17897	1.6	14.0	2347
	po	30	2	4572	18090	1.6			51
31c	iv	15			16235	1.4	15.0	1837
	po	30	2	101	383	NAd			1

^aC_max (maximum compound concentration) in blood plasma, AUC_obs (area under the curve), Cl_obs (Clearance), T_1/2 (half-life), V_ss (volume of distribution), F (oral bioavailability).

^b24 h experiments.

^c8 h experiment.

^dNot available due to compound concentration below detection level;