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. 2004 Jul 26;101(31):11471–11476. doi: 10.1073/pnas.0402941101

Fig. 6.

Fig. 6.

Potential mechanisms responsible for the cardioprotective effects on hTrx and its modification by S-nitrosation. (A) Effect of hTrx on ischemia/reperfusion-induced p38 MAPK activation and its modification by S-nitrosation. (Upper) Representative Western blot of phosphorylated ATF-2. (Lower) Quantitative densitometry of ≥5 independent experiments. **, P < 0.01 vs. MI/R plus vehicle; ##, P < 0.01 vs. MI/R plus hTrx. (B) Representative Western blots of S-nitrosated proteins from sham MI/R (lanes 1 and 2), MI/R plus vehicle (lanes 3 and 4), MI/R plus hTrx (lanes 5 and 6), and MI/R plus hTrx-SNO (lanes 7 and 8) as detected with a Nitro-Glo kit. An identical amount of protein was loaded on each lane (20 μg per lane).