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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Cancer Res. 2016 Sep 20;76(21):6183–6192. doi: 10.1158/0008-5472.CAN-15-3125

Figure 1.

Figure 1

Depletion of BPTF reduces 4T1 tumor weights in mice with CD8+ and CD4+ T cells. A, cartoon of NURF (BPTF, 2L, 48) bound to chromatin. Grey circles: histone modifications, TF: transcription factor. B, BPTF Western blot analysis from control (Ctrl-sh1, Ctrl-sh2) and BPTF KD (Bptf-sh1, Bptf-sh2) 4T1 total cell extracts. Cyclophilin B loading control. C-D, weights of primary control and BPTF KD 4T1 tumors after growth in C, BALB/c mice (n ≥ 12, * = ttest pvalue < 9.6×10−7) or D, NSG mice (n = 9). E, weights of 4T1 tumors after growth in undepleted, CD8+, CD4+ or asialo-GM1+ mAb depleted BALB/c mice. (n ≥ 5, * = ttest pvalue < 0.02).