Figure 2.
BPTF depletion reduces B16F10 tumor weights in mice with CD8+ and CD4+ T cells. A, BPTF Western blot analysis of control (Ctrl-sh1, Ctrl-sh2) and BPTF KD (Bptf-sh1, Bptf-sh2) B16F10 total cell extracts. Cyclophilin B loading control. B, weights of primary control and BPTF KD B16F10 tumors after growth in C57BL/6 mice (n ≥ 9, * = ttest pvalue < 1.4×10−7). C, weights of B16F10 tumors after growth in undepleted, CD8+, CD4+ or asialo-GM1+ mAb depleted C57BL/6 mice. (n ≥ 5, * = ttest pvalue < 0.02).