Table 1.
List of included case studies.
| Author | Surgery | N | Outcome | Comment |
|---|---|---|---|---|
| Dall et al. 2014 (36) |
Total hip | SSRI=83 Control=1202 |
Increase blood loss in patients on SSRI, mean = 93 ml (95% CI 38–147 ml) |
|
| Movig et al 2003 (37) |
Any orthopedic surgery |
SSRI=26 Control=474 |
Risk of transfusion increased in SSRI patients (OR 21.71, 95% CI 1.35–10.18) |
No increase in risk for patients on non-SSRI antidepressants |
| Sayadipour et al 2012 (38) |
Spinal fusion | SSRI or SNRI=144 Control=352 |
23% increased blood loss in SSRI or SNRI patients (p < .0001) |
|
| Schutte et al 2014 (39) |
Hip repair replacement |
SSRI=114 Control=352 |
Increased risk of transfusion in SSRI patients (OR 1.7, 95% CI 1.1–2.5) |
|
| Seitz et al 2013 (40) |
Hip fracture | SSRI=6668 Control=1900 (former SSRI users) |
Increased Risk of transfusions in current SSRI patients (OR 1.28, 95% CI 1.14–1.43) |
|
| Tavakoli et al 2012 (41) |
Hip and knee replacement |
SSRI=71 Control=123 Non-SSRI=29 |
No increased risk of bleeding or transfusions |
|
| Van Haelst et al 2010 (42) |
Hip Orthoplasty | SSRI=66 Non SSRI or SNRI=29 Control=285 |
Increased blood loss in SSRIs patients only (p< .01) |
|
| Andreasen et al 2006 (43) |
CABG | SSRI=124 Control=3320 |
No increase in transfusions (OR 1.1, 95% CI .9–1.5) |
SSRI use defined as medication within 90 days before surgery |
| Kim et al 2009 (44) |
CABG | SSRI=1076 Non-SSRI =304 antidepressant= 304 |
No increase in bleeding events SSRIs compared to non SSRI antidepressants (OR 1.03, 95% CI .6–1.78) |
Non SSRI group includes serotonin reuptake inhibitors, e.g. Amitriptyline |
| Tully etal 2012 (45) |
CABG | SSRI=105 Control=4031 |
No increase in bleeding events (p< .2) |
|
| Xiong et al 2010 (46) |
CABG | SSRI=246 Control=4542 |
No Difference in reoperation rate secondary to bleeding (OR 1.14, 95% CI .52–2.47) Volume of RBC units transfused greater in SSRI group (p < .001) |
|
| Gartner et al 2010 (47) |
Breast cancer | SSRI user=201 SSRI former user=1391 Control=12872 |
Increase risk for reoperation secondary to post-op bleeding in current SSRI users (OR. 2.3, 95% CI 1.4–2.4) No increases risk in former SSRI users |
|
| Basile et al 2013 (48) |
Cosmetic breast | SSRI=196 Control=2084 |
Increased risk in SSRI patients for breast hematoma needing intervention (OR 4.14, 95% CI 1.90–9.04) |
|
| Harirchian et al 2012 (49) |
Face lift | SSRI=60 Control=203 |
No difference in rate of post-operative hematomas |
|
| Salkeld et al 2008 (50) |
Postpartum Hemorrhage |
Post-partum Hemorrhage =2460 Control=23,943 |
No increase in post- partum hemorrhage for SSRI users (OR 1.30, 95% CI .98–1.72) |
SSRI use defined as medication taken within 90 days of delivery |
| Palmsten et al 2013 (51) |
Postpartum Hemorrhage |
Current SSRI=1495 Control=105,500 |
increased post- partum hemorrhage for current SSRI users (OR 1.47, 95% CI 1.33–1.62) |
No increase risk for past users of SSRIs |
| Napenas et al 2011 (52) |
Invasive dental treatment |
SSRI=92 No control |
2 bleeding events | |
| Richter et al 2011 (53\) |
Percutaneous endoscopic gastrostomy |
SSRI=99 Control=891 |
Increased risk of UGI bleeding in SSRI patients (OR 4.1, 95% CI 1.1–13.4) |